Folate and human reproduction

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Folate and human reproduction.

The influence of folate nutritional status on various pregnancy outcomes has long been recognized. Studies conducted in the 1950s and 1960s led to the recognition of prenatal folic acid supplementation as a means to prevent pregnancy-induced megaloblastic anemia. In the 1990s, the utility of periconceptional folic acid supplementation and folic acid food fortification emerged when they were pro...

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Role of folate receptor genes in reproduction and related cancers.

The expression patterns of folate receptor (FR) isoforms, alpha and beta, in normal and malignant male and female reproductive tissues is described. The significance of the receptor in reproductive and developmental physiology is discussed. The potential value of the receptor expressed in malignant tissues including ovarian and endometrial cancers as a diagnostic marker and a therapeutic target...

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Clarification of scope for Human Reproduction and Molecular Human Reproduction†.

As judged by any sentinel marker, ESHRE houses the most successful journals in reproductive health and disease, namely,Human Reproduction Update,Human Reproduction andMolecular Human Reproduction (MHR). This position has been achieved by continual publication of only the highest quality articles and constant innovation. With the change in editorship of all three ESHRE journals in 2013, the oppo...

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Folate during reproduction: the Canadian experience with folic acid fortification

Folate has received international attention regarding its role in the risk-reduction of birth defects, specifically neural tube defects (NTDs). In 1998, health officials in Canada, like the United States, mandated the addition of folic acid to white flour and select grain products to increase the folate intake of reproductive-aged women. Subsequent to this initiative there has been an increase ...

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Human Folate Bioavailability

The vitamin folate is recognized as beneficial health-wise in the prevention of neural tube defects, anemia, cardiovascular diseases, poor cognitive performance, and some forms of cancer. However, suboptimal dietary folate intake has been reported in a number of countries. Several national health authorities have therefore introduced mandatory food fortification with synthetic folic acid, which...

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ژورنال

عنوان ژورنال: The American Journal of Clinical Nutrition

سال: 2006

ISSN: 0002-9165,1938-3207

DOI: 10.1093/ajcn/83.5.993